Cohen-Addad N, Chatterjee M, Bekersky I, Blumenthal H P
Cancer Lett. 1986 Aug;32(2):151-4. doi: 10.1016/0304-3835(86)90113-8.
In-utero or immediate post-utero exposure of rats to saccharin results in an increased incidence of bladder tumors when compared to post-weaning exposure only. We studied 6 human mother-infant pairs following maternal intake of saccharin close to delivery. High performance liquid chromatography revealed the presence of saccharin in all 6 newborn cord sera as well as their mothers' sera and urine. This constitutes the first report of placental transfer of saccharin in humans. Despite the relative weakness in carcinogenicity of saccharin, this in-utero exposure, coupled with ex-utero exposure, may possibly contribute to an increased incidence of neoplasms.
与仅在断奶后接触糖精的大鼠相比，大鼠在子宫内或出生后立即接触糖精会导致膀胱肿瘤发病率增加。我们研究了6对母婴，这些母亲在分娩前摄入了糖精。高效液相色谱法显示，所有6例新生儿脐带血血清以及他们母亲的血清和尿液中都存在糖精。这是糖精在人类中胎盘转运的首次报道。尽管糖精的致癌性相对较弱，但这种子宫内接触加上子宫外接触，可能会导致肿瘤发病率增加。
