Bulatao-Jayme J, Almero E M, Castro M C, Jardeleza M T, Salamat L A
Int J Epidemiol. 1982 Jun;11(2):112-9. doi: 10.1093/ije/11.2.112.
The dietary intakes of 90 confirmed primary liver cancer cases were compared against 90 age-sex matched controls. Dietary recall, obtained by the same nutritionist, was taken for each change of residence lasting one year or more. The frequency and amounts of food items consumed were calculated into units of aflatoxin load per day using a Philippine table of aflatoxin values of these items. Of the total subjects' aflatoxin load, 51.2% came from cassava, 20.3% from corn, 6.8% from peanuts and 5.8% from sweet potato. The mean aflatoxin load per day of the cases as found to be 440% that of the controls. Upon grouping dietary aflatoxin loads (and alcohol intakes) into Heavy and Light, and upon comparing cases versus controls, the relative risk (RR) of developing primary liver cancer was found to be statistically significant in the following order of rank: cassava, peanuts, sweet potato, corn and alcohol. Boiled rice which had negligible aflatoxin content gave no difference in risk. Combining aflatoxin load and alcohol intake gave a synergistic and a statistically significant effect on RR with Light Aflatoxin, Light Alcohol as RR = 1.
Light Aflatoxin, Heavy Alcohol RR = 3.9; Heavy Aflatoxin, Light Alcohol RR = 17.5; Heavy Aflatoxin, Heavy Alcohol RR = 35.0.
将90例确诊的原发性肝癌患者的饮食摄入量与90名年龄和性别匹配的对照者进行比较。由同一位营养师通过饮食回顾法，对每次居住时间持续一年或更长时间的情况进行记录。食用的食物种类和数量，按照菲律宾这些食物的黄曲霉毒素含量表，换算为每天的黄曲霉毒素负荷单位。在所有受试者的黄曲霉毒素负荷中，51.2%来自木薯，20.3%来自玉米，6.8%来自花生，5.8%来自红薯。发现病例组每天的平均黄曲霉毒素负荷是对照组的440%。将饮食中的黄曲霉毒素负荷（以及酒精摄入量）分为高和低两组，并比较病例组和对照组，发现患原发性肝癌的相对风险（RR）在以下排序中具有统计学意义：木薯、花生、红薯、玉米和酒精。黄曲霉毒素含量可忽略不计的米饭在风险方面没有差异。将黄曲霉毒素负荷和酒精摄入量相结合，对RR产生协同且具有统计学意义的影响，低黄曲霉毒素、低酒精组的RR = 1。
低黄曲霉毒素、高酒精组的RR = 3.9；高黄曲霉毒素、低酒精组的RR = 17.5；高黄曲霉毒素、高酒精组的RR = 35.0。
