Doxepin and cimetidine in the treatment of duodenal ulcer: an open clinical and endoscopic study.

In an open clinical endoscopic study, 50 patients with duodenal ulcer showed no significant difference in ulcer healing during a 6-week treatment period with doxepin HCl (50 mg h.s.) versus cimetidine (1000 mg/day in divided doses). Possible tricyclic mechanisms of action in the treatment of peptic ulcer, e.g., histamine H2 blockade, are discussed.