Mangla J C, Pereira M
Arch Intern Med. 1982 Feb;142(2):273-5.
Doxepin hydrochloride was given to 12 patients with duodenal ulcer and one patient with an anastomotic ulcer. The dose of doxepin hydrochloride was 100 mg at bedtime, except in patients receiving hemodialysis, where only 50 mg at bedtime was given. Eight patients, including the four receiving hemodialysis, has not responded to treatment after eight weeks of cimetidine and/or antacid therapy. All patients (except one where a minor erosion was left in the duodenum) responded, and healing of the ulcer was demonstrated by endoscopy after four to six weeks of treatment. In two patients the ulcer recurred in four to eight weeks after discontinuation of doxepin therapy; however, ulcers healed after four weeks when therapy was reintroduced. Five previously untreated patients with duodenal ulcer were also given the same treatment. Four healed six weeks after starting doxepin therapy. In one patient the dose of doxepin hydrochloride had to be raised to 150 mg for complete healing.
将盐酸多塞平给予12例十二指肠溃疡患者和1例吻合口溃疡患者。盐酸多塞平的剂量为睡前100毫克，但接受血液透析的患者除外，这类患者睡前仅给予50毫克。包括4例接受血液透析的患者在内，8例患者在接受西咪替丁和/或抗酸剂治疗8周后对治疗无反应。所有患者（除1例十二指肠遗留轻度糜烂外）均有反应，治疗4至6周后经内镜检查证实溃疡愈合。2例患者在停用多塞平治疗4至8周后溃疡复发；然而，重新开始治疗4周后溃疡愈合。5例先前未经治疗的十二指肠溃疡患者也接受了相同的治疗。4例患者在开始多塞平治疗6周后愈合。1例患者为实现完全愈合，盐酸多塞平的剂量不得不增至150毫克。
