Shrivastava R K, Shah B K, Siegal H
Clin Ther. 1985;7(2):181-9.
Twenty-one patients with endoscopically proven active duodenal ulcers were studied in a double-blind randomized trial comparing doxepin hydrochloride (50 mg during the first week, and 100 mg thereafter, at bedtime) and cimetidine (1,200 mg/day in four divided doses). After two weeks, the average size of the ulcers had decreased 94% in the doxepin group (n = 8) versus 66% in the cimetidine group (n = 13) (P less than 0.01). After six weeks, the average size of the ulcers had decreased 97% in both the doxepin group (n = 5) and the cimetidine group (n = 10). Doxepin was significantly (P less than 0.01) more effective than cimetidine in women. Although cimetidine was less effective than doxepin, it was more effective in men than in women. Neither drug significantly altered ratings of the patients' anxiety or depression, most of which were within the normal range before and throughout treatment. Possible mechanisms of action of this tricyclic antidepressant and suggestions for its use in ulcer therapy are discussed.
在一项双盲随机试验中，对21例经内镜证实患有活动性十二指肠溃疡的患者进行了研究，比较了盐酸多塞平（第一周50毫克，此后每晚100毫克）和西咪替丁（每日1200毫克，分四次服用）的疗效。两周后，多塞平组（n = 8）溃疡的平均大小减小了94%，而西咪替丁组（n = 13）减小了66%（P < 0.01）。六周后，多塞平组（n = 5）和西咪替丁组（n = 10）溃疡的平均大小均减小了97%。在女性患者中，多塞平的疗效显著优于西咪替丁（P < 0.01）。虽然西咪替丁的疗效不如多塞平，但在男性患者中比在女性患者中更有效。两种药物均未显著改变患者的焦虑或抑郁评分，大多数患者在治疗前及整个治疗过程中的评分均在正常范围内。本文讨论了这种三环类抗抑郁药可能的作用机制及其在溃疡治疗中的应用建议。
