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将二甲基肼诱导的小鼠肿瘤作为结直肠癌模型系统的评估。

Evaluation of dimethylhydrazine induced tumours in mice as a model system for colorectal cancer.

作者信息

Haase P, Cowen D M, Knowles J C, Cooper E H

出版信息

Br J Cancer. 1973 Dec;28(6):530-43. doi: 10.1038/bjc.1973.183.

DOI:10.1038/bjc.1973.183
PMID:4131500
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2008945/
Abstract

The evolution and structure of adenomatous polyps and adenocarcinomata of the colon in NMRI mice induced by dimethylhydrazine are described. Severe toxic reactions in the liver and other organs are produced by dimethylhydrazine (DMH), but tumours are induced only in the colon and around the anus. The 100% incidence and growth characteristics of the tumours make it potentially a good model system, but investigators should take into account the widespread nonspecific cellular injury induced by this carcinogen.

摘要

描述了由二甲基肼诱导的NMRI小鼠结肠腺瘤性息肉和腺癌的演变及结构。二甲基肼（DMH）会在肝脏和其他器官产生严重的毒性反应，但仅在结肠和肛门周围诱发肿瘤。肿瘤100%的发生率及生长特性使其有可能成为一个良好的模型系统，但研究人员应考虑到这种致癌物所引起的广泛非特异性细胞损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/3cd3ec9490d9/brjcancer00345-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/64f25071e1a7/brjcancer00345-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/4cfb1fd1d553/brjcancer00345-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/036084ad4f19/brjcancer00345-0058-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/7a17237385e4/brjcancer00345-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/4fcf0cde4f55/brjcancer00345-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/1331b7573a9e/brjcancer00345-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/85b4f2686d55/brjcancer00345-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/3cd3ec9490d9/brjcancer00345-0063-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/64f25071e1a7/brjcancer00345-0064-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/4cfb1fd1d553/brjcancer00345-0058-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/036084ad4f19/brjcancer00345-0058-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/7a17237385e4/brjcancer00345-0059-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/4fcf0cde4f55/brjcancer00345-0060-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/1331b7573a9e/brjcancer00345-0061-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/85b4f2686d55/brjcancer00345-0062-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05c5/2008945/3cd3ec9490d9/brjcancer00345-0063-a.jpg

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本文引用的文献

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An electron microscope study of intranuclear inclusions in mouse liver and hepatoma.小鼠肝脏和肝癌细胞核内包涵体的电子显微镜研究。
J Biophys Biochem Cytol. 1959 Dec;6(3):427-30. doi: 10.1083/jcb.6.3.427.
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ULTRASTRUCTURE OF ADENOMATOUS POLYPS AND VILLOUS ADENOMAS OF THE LARGE INTESTINE.大肠腺瘤性息肉和绒毛状腺瘤的超微结构
Gastroenterology. 1965 Feb;48:188-97.
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Ultrastructure of adenocarcinoma of the colon.结肠腺癌的超微结构
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Br J Cancer. 1980 Jul;42(1):95-102. doi: 10.1038/bjc.1980.207.
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The assessment of response of murine transplantable colon tumors to combination chemotherapy.小鼠可移植性结肠肿瘤对联合化疗反应的评估。
J Cancer Res Clin Oncol. 1982;103(2):119-26. doi: 10.1007/BF00409642.
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Development and cell kinetics of colonic tumors induced in mice by dimethylhydrazine.二甲基肼诱导小鼠结肠肿瘤的发生与细胞动力学
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Glycosidases in normal and dimethylhydrazine-treated rats and mice with special reference to the colonic tumours.正常及二甲基肼处理的大鼠和小鼠体内的糖苷酶，特别涉及结肠肿瘤
Br J Cancer. 1974 Jun;29(6):438-46. doi: 10.1038/bjc.1974.96.
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The alkylation of nucleic acids of rat and mouse in vivo by the carcinogen 1,2-dimethylhydrazine.致癌物1,2 - 二甲基肼对大鼠和小鼠体内核酸的烷基化作用。
Br J Cancer. 1974 Nov;30(5):440-7. doi: 10.1038/bjc.1974.218.
10
Morphological and biochemical effects of 1,2-dimethylhydrazine and 1-methylhydrazine in rats and mice.1,2 - 二甲基肼和1 - 甲基肼对大鼠和小鼠的形态学及生化影响。
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[Production of tumors in the intestines of mice by 1,2-dimethylhydrazine].[1,2 - 二甲基肼在小鼠肠道中诱发肿瘤]
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[Morphological and autoradiographic investigation of alterations of intestinal mucosa after a single injection of 1,2-dimethylhydrazine].[单次注射1,2-二甲基肼后肠黏膜改变的形态学与放射自显影研究]
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Increased transfer ribonucleic acid methylase activity in tumours induced in the mouse colon by the administration of 1,2-dimethylhydrazine.通过给予1,2 - 二甲基肼在小鼠结肠诱导的肿瘤中，转移核糖核酸甲基酶活性增加。
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