对年轻男性的血脂水平进行了32年的跟踪研究。
Blood lipids in young men followed 32 years.
作者信息
Gillum R F, Taylor H L, Brozek J, Anderson J, Blackburn H
出版信息
J Chronic Dis. 1982;35(8):635-41. doi: 10.1016/0021-9681(82)90015-7.
The relationship of baseline characteristics to serum cholesterol at baseline (CHL47) when aged 16-25 (mean 20.5) yr and at 32-yr follow-up (CHL79) was assessed in 162 men. Mean CHL rose over the follow-up period. CHL47 predicted CHL79 (r = 0.61, p less than 0.001) but not CHL79-CHL47. The mean (+/- SD) weight change (DW) was 12.0 kg (+/- 26.0 kg). DW was not significantly related to CHL47, but was independently related to CHL79-CHL47 (4 = 0.30, p less than 0.001). Age, height, DW, any of 7 measures of baseline obesity and CHL47 predicted CHL79 with R2 of 0.40 and CHL79-CHL47 with R2 of 0.37. Thus, weight change but not baseline relative weight was a determinant of serum cholesterol change from youth to middle age. There was strong tracking of serum cholesterol over this period.
在162名男性中评估了16至25岁（平均20.5岁）时的基线特征与基线血清胆固醇（CHL47）以及32年随访时（CHL79）的关系。在随访期间，平均CHL有所上升。CHL47可预测CHL79（r = 0.61，p<0.001），但不能预测CHL79-CHL47。平均（±标准差）体重变化（DW）为12.0千克（±26.0千克）。DW与CHL47无显著相关性，但与CHL79-CHL47独立相关（r = 0.30，p<0.001）。年龄、身高、DW、7种基线肥胖测量指标中的任何一项以及CHL47对CHL79的预测R2为0.40，对CHL79-CHL47的预测R2为0.37。因此，体重变化而非基线相对体重是从青年到中年血清胆固醇变化的决定因素。在此期间，血清胆固醇有很强的追踪性。
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