氨基乙腈对核酸烷基化作用及1,2 - 二甲基肼代谢的抑制作用
Inhibition of the alkylation of nucleic acids and of the metabolism of 1,2-dimethylhydrazine by aminoacetonitrile.
作者信息
Pegg A E
出版信息
Chem Biol Interact. 1978 Nov;23(2):273-9. doi: 10.1016/0009-2797(78)90014-5.
PMID:709691
Abstract
Pretreatment of rats with aminoacetonitrile inhibited the metabolism of [14C]1,2-dimethylhydrazine to 14CO2 and increased the expiration of [14C]-azomethane. Alkylation of nucleic acids following administration of 1,2-dimethylhydrazine was reduced by aminoacetonitrile to 5% of control levels in liver, 11% of control levels in kidney and 43% of control levels in colon.
摘要
用氨基乙腈对大鼠进行预处理可抑制[14C]1,2 - 二甲基肼向14CO2的代谢，并增加[14C] - 偶氮甲烷的呼出量。给予1,2 - 二甲基肼后核酸的烷基化程度，在肝脏中被氨基乙腈降低至对照水平的5%，在肾脏中降至对照水平的11%，在结肠中降至对照水平的43%。
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