Taga M
Nihon Sanka Fujinka Gakkai Zasshi. 1982 Jun;34(6):709-18.
Although it is well established that PRL is present in the maternal serum, fetal serum, and amniotic fluid during human pregnancy, the precise interrelationship among those three compartments is unknown. In order to elucidate the intercompartmental relationship, several experiments were undertaken. Results are as follows: 2. The concentration of amniotic fluid PRL was different from that of maternal or fetal serum PRL during gestation. 2. There was no correlation between amniotic fluid and maternal or cord serum PRL at delivery. 3. Although bromocriptine suppressed the secretion of maternal serum PRL abruptly, the concentration of amniotic fluid PRL remained unchanged after the administration of bromocriptine at mid-gestation. 4. Analysis of molecular size of PRL by Sephadex G-100 column gel filtration revealed that the elution profiles of maternal serum PRL, fetal serum PRL, and amniotic fluid PRL differed from one another and furthermore, they were similar to those of adult pituitary PRL, fetal pituitary PRL, and decidual PRL, respectively. 5. PRL which was secreted from decidua could transfer to amniotic cavity across the fetal membrane. 6. Decidual PRL and amniotic fluid PRL have a biological activity. These results suggest that three compartments of PRL secretion during human pregnancy are independent each other and, furthermore, possible origin of amniotic fluid PRL is decidua.
虽然已有充分证据表明，在人类怀孕期间，母体血清、胎儿血清和羊水中均存在催乳素（PRL），但这三个腔室之间的确切相互关系尚不清楚。为了阐明各腔室之间的关系，我们进行了多项实验。结果如下：2. 在妊娠期，羊水PRL的浓度与母体或胎儿血清PRL的浓度不同。2. 在分娩时，羊水与母体或脐带血清PRL之间无相关性。3. 虽然溴隐亭可突然抑制母体血清PRL的分泌，但在妊娠中期给予溴隐亭后，羊水PRL的浓度保持不变。4. 通过Sephadex G - 100柱凝胶过滤分析PRL的分子大小，结果显示母体血清PRL、胎儿血清PRL和羊水PRL的洗脱图谱各不相同，而且，它们分别与成人垂体PRL、胎儿垂体PRL和蜕膜PRL的洗脱图谱相似。5. 由蜕膜分泌的PRL可穿过胎膜转移至羊膜腔。6. 蜕膜PRL和羊水PRL具有生物活性。这些结果表明，人类怀孕期间PRL分泌的三个腔室相互独立，而且，羊水PRL的可能来源是蜕膜。
