Kohno Y, Tanaka M, Nakagawa R, Ida Y, Iimori K, Nagasaki N
J Neurochem. 1982 Sep;39(3):878-81. doi: 10.1111/j.1471-4159.1982.tb07975.x.
Developmental changes in brain levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) were studied in rats. In most brain regions, MHPG-SO4 level rapidly increased to approach or exceed adult levels at the time of weaning, while NA levels increased more gradually and reached adult levels following weaning. Pharmacological studies showed that the MHPG-SO4 level in the neonatal brain reflects the degradation of released NA. The developmental characteristics of noradrenergic neurons in eight discrete brain regions are discussed.
对大鼠脑中去甲肾上腺素（NA）和3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4）的发育变化进行了研究。在大多数脑区，MHPG-SO4水平在断奶时迅速升高，接近或超过成年水平，而NA水平升高较为缓慢，断奶后达到成年水平。药理学研究表明，新生脑内的MHPG-SO4水平反映了释放的NA的降解情况。本文讨论了八个离散脑区中去甲肾上腺素能神经元的发育特征。
