三环类抗抑郁药急性和慢性治疗对大鼠脑不同区域3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4）含量的影响。

Effect of acute and chronic treatment with tricyclic antidepressants on 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) contents in various regions of rat brain.

Miyauchi T, Kitada Y, Satoh S

Prog Neuropsychopharmacol Biol Psychiatry. 1982;6(2):137-42. doi: 10.1016/s0278-5846(82)80189-9.

Abstract

Effects of acute and chronic treatment with desipramine (DMI) and amitriptyline (AMI) on 3-methoxy-4-hydroxyphenylethyleneglycol sulfate (MHPG-SO4) levels in eight brain regions were examined in rats. 2. A single injection of DMI decreased MHPG-SO4 levels in all brain regions except the midbrain, whereas the effect disappeared after the chronic treatment except in the septal area. MHPG-SO4 levels in the hippocampus and thalamus were increased after the chronic treatment with the drug. 3. A single and chronic administration of AMI decreased MHPG-SO4 levels in the thalamus and hippocampus, respectively. 4. These results indicate that the effects of acute and chronic treatment with the tricyclic antidepressants on the central noradrenergic systems differ in different regions of rat brain.

摘要

研究了去甲丙咪嗪（DMI）和阿米替林（AMI）急性及慢性给药对大鼠八个脑区中3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4）水平的影响。2. 单次注射DMI可降低除中脑外所有脑区的MHPG-SO4水平，而慢性给药后该效应消失，但隔区除外。慢性给药后海马体和丘脑的MHPG-SO4水平升高。3. 单次和慢性给予AMI分别降低了丘脑和海马体中的MHPG-SO4水平。4. 这些结果表明，三环类抗抑郁药急性和慢性给药对大鼠脑不同区域的中枢去甲肾上腺素能系统的影响有所不同。