Kohno Y, Tanaka M, Nakagawa R, Toshima N, Nagasaki N
J Neurochem. 1981 Jan;36(1):286-9. doi: 10.1111/j.1471-4159.1981.tb02405.x.
The levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) in 15 brain regions showed a parallel distribution in male Wistar rats. The differences in regional distribution of MHPG-SO4 were similar to those in the rate of NA turnover reported by other investigators. The accumulation rates of MHPG-SO4 during 45 and 90 min after probenecid injection significantly correlated to the steady state levels of MHPG-SO4 in nine regions studied. With the results, the regional levels of MHPG-SO4 either in untreated or in probenecid-treated rats, are considered to be a useful index of NA turnover.
在雄性Wistar大鼠的15个脑区中，去甲肾上腺素（NA）和3-甲氧基-4-羟基苯乙二醇硫酸盐（MHPG-SO4）的水平呈平行分布。MHPG-SO4的区域分布差异与其他研究者报道的NA周转率差异相似。丙磺舒注射后45分钟和90分钟内MHPG-SO4的积累速率与所研究的9个区域中MHPG-SO4的稳态水平显著相关。基于这些结果，未处理或丙磺舒处理大鼠中MHPG-SO4的区域水平被认为是NA周转率的一个有用指标。
