Petro T M, Watson R R
J Nutr. 1982 Aug;112(8):1498-505. doi: 10.1093/jn/112.8.1498.
The native and acquired cell-mediated immune resistance against Listeria monocytogenes steadily developed in young mice after weaning and reached maximum activity at 6 and 12 weeks of age, respectively. Mice fed a high fat (20% corn oil) diet from 3 weeks of age had a significantly more rapid development of resistance against L. monocytogenes. Mice fed the high fat diet beginning at 6 and 12 weeks of age had significantly lower native preimmune resistance against L. monocytogenes after 3 weeks on the diet. On the other hand, 3-week-old mice fed a low protein (4% casein) diet had a significantly retarded development of native and acquired resistance against L. monocytogenes. However, mice consuming the low protein diet at 6, 12 or 24 weeks of age did not exhibit an impairment in this resistance. Therefore age at which the dietary stress, either low protein or high fat, was initiated had an important effect on native and acquired resistance of mice against L. monocytogenes.
断奶后的幼鼠对单核细胞增生李斯特菌的天然和获得性细胞介导免疫抵抗力稳步发展，分别在6周龄和12周龄时达到最大活性。从3周龄开始喂食高脂肪（20%玉米油）饮食的小鼠对单核细胞增生李斯特菌的抵抗力发展明显更快。从6周龄和12周龄开始喂食高脂肪饮食的小鼠在饮食3周后对单核细胞增生李斯特菌的天然免疫前抵抗力显著降低。另一方面，喂食低蛋白（4%酪蛋白）饮食的3周龄小鼠对单核细胞增生李斯特菌的天然和获得性抵抗力发展明显迟缓。然而，在6、12或24周龄时食用低蛋白饮食的小鼠在这种抵抗力方面未表现出损害。因此，开始施加低蛋白或高脂肪饮食应激的年龄对小鼠对单核细胞增生李斯特菌的天然和获得性抵抗力有重要影响。
