Loutit J F, Howells G R, Green D
J Pathol. 1982 Jul;137(3):217-24. doi: 10.1002/path.1711370306.
Two groups of syngeneic radiation chimaeras were established, the reconstitution being with spleen from osteopetrotic mice on the one hand and normal bone marrow on the other. Induced osteopetrosis in the former was evident radiologically not only as metaphyseal opacity but as unduly dense cortices compared with the latter, particularly terminally after 16-18 months. The radiological impressions were confirmed by measurement of cortical thickness in both longitudinal and transverse sections of undecalcified femoral shafts. Measurements were made with a Quantimet-720 System-30 Image Analyser. Terminally the differences were highly significant. One concludes that defective osteoclasts of osteopetrotic mice derived from haematopoietic stem cells fail to resorb not only primitive woven bone but also cortical laminar bone.
建立了两组同基因辐射嵌合体，一组用骨石化小鼠的脾脏进行重建，另一组用正常骨髓进行重建。前一组诱导的骨石化在放射学上不仅表现为干骺端模糊，而且与后一组相比，皮质骨过度致密，特别是在16 - 18个月后的末期。通过测量未脱钙股骨干纵剖面和横剖面的皮质厚度，证实了放射学印象。使用Quantimet - 720系统 - 30图像分析仪进行测量。末期差异非常显著。由此得出结论，源自造血干细胞的骨石化小鼠的破骨细胞缺陷不仅无法吸收原始编织骨，也无法吸收皮质板层骨。
