Walker D G
Science. 1975 Nov 21;190(4216):785-7. doi: 10.1126/science.1198094.
Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts.
通过将来自患骨石化症同窝仔鼠脾脏制备的细胞悬液注入经致死剂量照射的灰色致死和小眼症品系的正常小鼠，诱发了骨石化症。移植后几周内，骨骼重塑失败变得明显，因为钙化软骨和骨在长骨活跃的干骺端过度积聚。所产生的大量病变被异常破骨细胞广泛浸润。
