Das Gupta V
J Pharm Sci. 1982 May;71(5):585-7. doi: 10.1002/jps.2600710526.
The stability of benzoyl peroxide in polyethylene glycol ointment base and some liquid vehicles (acetone, ethanol, propylene glycol, and their mixtures) was studied. Some solutions also contained an additional ingredient (acetanilide, benzoic acid, chlorhydroxyquinoline, and hydroxyquinoline) as a possible stabilizer. Benzoyl peroxide decomposed very fast (first-order K value 0.028 day-1 at 24 degrees) in polyethylene glycol ointment base. At 50 degrees, the potency of benzoyl peroxide in polyethylene glycol ointment base decreased to less than 1% in 5 days. Decomposition in solutions is complex. Considering acetone as a standard vehicle, ethanol improved the stability of benzoyl peroxide and propylene glycol had an adverse effect on the stability. Of the stabilizers studied, only chlorhydroxyquinoline improved the stability.
研究了过氧化苯甲酰在聚乙二醇软膏基质和一些液体载体（丙酮、乙醇、丙二醇及其混合物）中的稳定性。一些溶液还含有一种额外成分（乙酰苯胺、苯甲酸、氯羟基喹啉和羟基喹啉）作为可能的稳定剂。过氧化苯甲酰在聚乙二醇软膏基质中分解非常快（24℃时一级反应K值为0.028天-1）。在50℃时，聚乙二醇软膏基质中过氧化苯甲酰的效价在5天内降至1%以下。溶液中的分解情况很复杂。以丙酮作为标准载体，乙醇提高了过氧化苯甲酰的稳定性，而丙二醇对稳定性有不利影响。在所研究的稳定剂中，只有氯羟基喹啉提高了稳定性。
