Quantitative determination of benzoyl peroxide by high-performance liquid chromatography and comparison to the iodometric method.

A selective high-performance liquid chromatographic (HPLC) procedure for the quantitative determination of benzoyl peroxide in pharmaceutical dosage forms is described. Benzoyl peroxide was dissolved or extracted in the presence of an internal standard, acenaphthylene. The specificity of the stability-indicating HPLC and iodometric procedures are presented for benzoyl peroxide.