Bollinger J N, Lewis D, Mendez V M
J Pharm Sci. 1977 May;66(5):718-22. doi: 10.1002/jps.2600660528.
The storage stability of benzoyl peroxide in the presence of both individual and combined pharmaceutical gel ingredients was investigated. Benzoyl peroxide was quite unstable in the presence of nucleophilic agents and certain acidic substances. At both 30 and 40 degrees storage temperatures, benzoyl peroxide was destroyed rapidly (within 1 month) in the presence of ethanol and acidic chelating agents. The substitution of acetone for ethanol, the elimination of chelating agents, and the addition of sodium hydroxide to gel preparations markedly reduced degradation.
研究了在单一和组合药物凝胶成分存在下过氧化苯甲酰的储存稳定性。过氧化苯甲酰在亲核试剂和某些酸性物质存在下相当不稳定。在30和40摄氏度的储存温度下，过氧化苯甲酰在乙醇和酸性螯合剂存在下迅速被破坏（1个月内）。用丙酮替代乙醇、去除螯合剂以及在凝胶制剂中添加氢氧化钠可显著减少降解。
