Robinson J P, Penny R
J Clin Lab Immunol. 1982 Apr;7(3):219-21.
We have used chemiluminescence (CL) as a model for assessing the effects of paraproteins on human neutrophils and monocytes. A difference in the response of these two cell types was demonstrated. Paraprotein-containing sera (classes IgG, IgA and IgM) depressed the CL response of monocytes in almost all cases but had no effect on neutrophils. This effect was reproduced using purified paraprotein and showed a dose dependent response. It is proposed that this difference may be a function of the interaction between paraprotein and differing membrane receptors in phagocytes.
我们使用化学发光（CL）作为模型来评估副蛋白对人中性粒细胞和单核细胞的影响。结果表明这两种细胞类型的反应存在差异。含副蛋白的血清（IgG、IgA和IgM类）在几乎所有情况下都会抑制单核细胞的CL反应，但对中性粒细胞没有影响。使用纯化的副蛋白可重现这种效应，且呈现剂量依赖性反应。有人提出，这种差异可能是副蛋白与吞噬细胞中不同膜受体之间相互作用的结果。
