实验性重症肌无力受受体 - 抗受体复合物抑制。
Experimental myasthenia gravis is inhibited by receptor-antireceptor complexes.
作者信息
Barkas T, Simpson J A
出版信息
J Clin Lab Immunol. 1982 Apr;7(3):223-7.
PMID:7097749
Abstract
Experimental autoimmune myasthenia gravis (EAMG) induced in rabbits by immunisation with purified nicotinic acetylcholine receptor from Torpedo marmorata is a highly reproducible model for the human disease. Pretreatment of experimental animals with immune complexes containing receptor and anti-receptor antibodies suppressed the subsequent induction of EAMG. Animals were protected from the normal severe paralysis. Moreover, antibody levels were reduced by synthesis of antibody rapidly terminated. Possible mechanisms are discussed.
摘要
用纯化的电鳐烟碱型乙酰胆碱受体免疫家兔诱导的实验性自身免疫性重症肌无力（EAMG）是人类疾病的一种高度可重复的模型。用含有受体和抗受体抗体的免疫复合物对实验动物进行预处理可抑制随后EAMG的诱导。动物免受正常的严重麻痹。此外，抗体水平因抗体合成迅速终止而降低。文中讨论了可能的机制。
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Experimental myasthenia gravis is inhibited by receptor-antireceptor complexes.实验性重症肌无力受受体 - 抗受体复合物抑制。
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