异种抗独特型抗血清证明抗乙酰胆碱受体抗体在受体结合位点不存在动物间交叉反应：对重症肌无力免疫治疗的意义
Lack of inter-animal cross-reaction of anti-acetylcholine receptor antibodies at the receptor-binding site as demonstrated by heterologous anti-idiotype antisera: implications for immunotherapy of myasthenia gravis.
作者信息
Barkas T, Simpson J A
出版信息
Clin Exp Immunol. 1982 Jan;47(1):119-26.
Abstract
Anti-idiotype antisera were raised in rabbits by immunization with purified sheep anti-Torpedo receptor antibodies. The antisera were able specifically to block the binding of receptor to the inducing antibodies but not anti-Torpedo antibodies from other animals of the same, or other, species. Rabbits producing the anti-idiotype sera were not protected from experimental autoimmune myasthenia gravis (EAMG). The implications of these observations for the potential use of anti-idiotype antisera in the treatment of myasthenia gravis are discussed.
摘要
通过用纯化的羊抗电鳐受体抗体免疫兔子来制备抗独特型抗血清。这些抗血清能够特异性地阻断受体与诱导抗体的结合，但不能阻断来自相同或其他物种的其他动物的抗电鳐抗体的结合。产生抗独特型血清的兔子未免受实验性自身免疫性重症肌无力（EAMG）的影响。讨论了这些观察结果对于抗独特型抗血清在重症肌无力治疗中的潜在应用的意义。
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本文引用的文献
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Restrictions in the response to autologous thyroglobulin in the human.人体对自身甲状腺球蛋白反应的限制。
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