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实验性自身免疫性重症肌无力兔体内两种不同亚群抗乙酰胆碱受体抗体的研究。

Study of two different subpopulations of anti-acetylcholine receptor antibodies in a rabbit with experimental auto-immune myasthenia gravis.

作者信息

Zurn A D, Fulpius B W

出版信息

Eur J Immunol. 1977 Aug;7(8):529-32. doi: 10.1002/eji.1830070807.

DOI:10.1002/eji.1830070807
PMID:902680
Abstract

Two different subpopulations of anti-acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin-binding site of the receptor might play a role in the appearance of the paralysis observed in this particular case.

摘要

在一只用鱼雷乙酰胆碱受体免疫的兔子的实验性自身免疫性重症肌无力发展过程中,研究了两种不同亚群的抗乙酰胆碱受体抗体。结果表明,针对受体毒素结合位点的抗体亚群可能在该特定病例中观察到的麻痹症状出现过程中起作用。

相似文献

1
Study of two different subpopulations of anti-acetylcholine receptor antibodies in a rabbit with experimental auto-immune myasthenia gravis.实验性自身免疫性重症肌无力兔体内两种不同亚群抗乙酰胆碱受体抗体的研究。
Eur J Immunol. 1977 Aug;7(8):529-32. doi: 10.1002/eji.1830070807.
2
Specificities of antibody to acetylcholine receptor in rabbits with experimental myasthenia gravis.实验性重症肌无力兔中乙酰胆碱受体抗体的特异性
Clin Exp Immunol. 1980 Jul;41(1):13-8.
3
Inhibition of alpha-bungarotoxin binding to acetylcholine receptors by antisera from animals with experimental autoimmune myasthenia gravis.实验性自身免疫性重症肌无力动物抗血清对α-银环蛇毒素与乙酰胆碱受体结合的抑制作用。
J Supramol Struct. 1980;14(3):267-79. doi: 10.1002/jss.400140302.
4
Antibodies to the acetylcholine receptor molecule and its component polypeptide chains.抗乙酰胆碱受体分子及其组成多肽链的抗体。
Adv Cytopharmacol. 1979;3:245-53.
5
Experimental myasthenia gravis is inhibited by receptor-antireceptor complexes.实验性重症肌无力受受体 - 抗受体复合物抑制。
J Clin Lab Immunol. 1982 Apr;7(3):223-7.
6
Lack of inter-animal cross-reaction of anti-acetylcholine receptor antibodies at the receptor-binding site as demonstrated by heterologous anti-idiotype antisera: implications for immunotherapy of myasthenia gravis.异种抗独特型抗血清证明抗乙酰胆碱受体抗体在受体结合位点不存在动物间交叉反应:对重症肌无力免疫治疗的意义
Clin Exp Immunol. 1982 Jan;47(1):119-26.
7
Immunological studies of acetylcholine receptors.乙酰胆碱受体的免疫学研究。
J Supramol Struct. 1976;4(3):389-403. doi: 10.1002/jss.400040310.
8
Myasthenia induced by monoclonal anti-acetylcholine receptor antibodies: clinical and electrophysiological aspects.单克隆抗乙酰胆碱受体抗体诱发的肌无力:临床和电生理方面
Ann Neurol. 1981 Jun;9(6):563-8. doi: 10.1002/ana.410090609.
9
[Clinical correlation of anti-receptor antibody titer, sensitivity to curare and electromyographic changes in experimental autoimmune myasthenia gravis].[实验性自身免疫性重症肌无力中抗受体抗体滴度、对箭毒的敏感性与肌电图变化的临床相关性]
Zhonghua Shen Jing Jing Shen Ke Za Zhi. 1990 Oct;23(5):293-6, 320.
10
The role of acetylcholine receptor antibodies in myasthenia gravis.乙酰胆碱受体抗体在重症肌无力中的作用。
Fed Proc. 1979 Sep;38(10):2381-5.

引用本文的文献

1
Myasthenia gravis. Anti-acetylcholine receptor antibodies.重症肌无力。抗乙酰胆碱受体抗体。
Ital J Neurol Sci. 1981 May;2(2):165-71. doi: 10.1007/BF02335439.
2
Anti-acetylcholine receptor antibodies directed against the alpha-bungarotoxin binding site induce a unique form of experimental myasthenia.针对α-银环蛇毒素结合位点的抗乙酰胆碱受体抗体可诱发一种独特形式的实验性肌无力。
Proc Natl Acad Sci U S A. 1983 Jul;80(13):4089-93. doi: 10.1073/pnas.80.13.4089.
3
Properties of end-plate channels in rats immunized against acetylcholine receptors.
抗乙酰胆碱受体免疫大鼠终板通道的特性
J Physiol. 1981 Feb;311:251-66. doi: 10.1113/jphysiol.1981.sp013583.
4
Protective effect of myasthenic immunoglobulins against the lethal toxicity of alpha bungarotoxin.重症肌无力免疫球蛋白对α-银环蛇毒素致死毒性的保护作用。
Clin Exp Immunol. 1987 Apr;68(1):130-7.