Caffee H H, Bingham H G
J Trauma. 1982 Jul;22(7):586-7. doi: 10.1097/00005373-198207000-00010.
The relationship of silver sulfadiazine therapy to leukopenia has been controversial. In our burn unit the incidence of leukopenia increased dramatically in 1978. Leukopenia was observed only in silver sulfadiazine-treated patients and not in patients treated with other agents. Because cimetidine had been introduced at about that time, the possibility of a drug interaction was investigated with a prospective randomized study. It was found that leukopenia continued to appear in a large percentage of patients in both groups, although the incidence was higher in cimetidine-treated patients.
磺胺嘧啶银疗法与白细胞减少症之间的关系一直存在争议。在我们的烧伤病房，1978年白细胞减少症的发病率急剧上升。仅在接受磺胺嘧啶银治疗的患者中观察到白细胞减少症，而接受其他药物治疗的患者中未观察到。由于大约在那个时候引入了西咪替丁，因此通过前瞻性随机研究调查了药物相互作用的可能性。结果发现，两组中仍有很大比例的患者出现白细胞减少症，尽管西咪替丁治疗组的发病率更高。
