Jarrett F, Ellerbe S, Demling R
Am J Surg. 1978 Jun;135(6):818-9. doi: 10.1016/0002-9610(78)90173-3.
Leukopenia, with a mean white blood cell count of 2,680/mm3, was observed in nine patients with thermal injury early in the course of topical treatment with silver sulfadiazine. All manifested absolute neutropenia with a concomitant increase in immature band forms in the peripheral blood smear. The leukocyte counts returned to within normal limits within 48 to 72 hours of discontinuation of silver sulfadiazine therapy in four patients, and also did so in five patients in whom silver sulfadiazine therapy was continued. Leukopenia secondary to silver sulfadiazine application is currently believed to be an innocuous, self-limited phenomenon.
在9例热烧伤患者局部应用磺胺嘧啶银治疗的早期过程中，观察到白细胞减少，平均白细胞计数为2680/mm³。所有患者均表现为绝对中性粒细胞减少，同时外周血涂片显示未成熟带状核细胞增多。4例患者在停用磺胺嘧啶银治疗后48至72小时内白细胞计数恢复至正常范围，另外5例继续使用磺胺嘧啶银治疗的患者白细胞计数也恢复正常。目前认为，应用磺胺嘧啶银继发的白细胞减少是一种无害的、自限性现象。
