Terner U K, Wiebe L I, Noujaim A A, Dssetor J B, Sanders E J
Clin Biochem. 1978 Aug;11(4):156-8. doi: 10.1016/s0009-9120(78)90366-1.
The activity of the hepatic microsomal enzymes hexabarbital oxidase, aminopyrine demethylase, and p-nitrobenzoic acid reductase were determined in the chronically uremic rats, acutely uremic rats and controls. Plasma corticoid levels (corticosterone) were also measured in all groups. A significant reduction in the hepatic microsomal enzyme activity as compared to controls was observed in both groups, with the chronic group showing slightly greater reduction. Furthermore, while plasma corticoid levels were significantly elevated in both groups, the acute uremic group had plasma corticoid levels which were almost twice the levels found in the chronically uremic animals. The significance of these observations are discussed.
在慢性尿毒症大鼠、急性尿毒症大鼠和对照组中，测定了肝微粒体酶六巴比妥氧化酶、氨基比林脱甲基酶和对硝基苯甲酸还原酶的活性。还测量了所有组的血浆皮质激素水平（皮质酮）。与对照组相比，两组肝微粒体酶活性均显著降低，慢性组的降低幅度略大。此外，虽然两组血浆皮质激素水平均显著升高，但急性尿毒症组的血浆皮质激素水平几乎是慢性尿毒症动物的两倍。讨论了这些观察结果的意义。
