Tse J W, Wiebe L I, Shysh A
Eur J Nucl Med. 1979 Jun 1;4(3):199-201. doi: 10.1007/BF00620485.
The chronic uremic condition was induced in male Wistar rats by long term maintenance of the animals following sequential sub-total and contralateral nephrectomies. Hepatic reticuloendothelial (RES) activity was estimated by non-invasive measurement of blood clearance rates and hepatic uptake of 99Tcm sulfur colloid administered intravenously. The blood half-time, and the blood clearance rate constants for normals and chronic uremics were 78 +/- 10 s and 49.5 +/- 5 s, and 7.51 +/- 1.04 x 10(-3) s-1 and 10.81 +/- 1.17 x 10(-3) s-1 respectively. The normal hepatic uptake rate constant was 9.03 +/- 1.25 x 10(-3) s-1, compared with a uremic uptake rate constant of 14.34 +/- 1.51 s-1. Measurement of total liver radioactivity upon termination, 15 min after injection, showed significantly increased total uptake in uremia, whereas no change in spleen radioactivity was observed. The clinical implications of these data are discussed.
通过对雄性Wistar大鼠先后进行次全肾切除术和对侧肾切除术，并长期饲养，诱导其出现慢性尿毒症状态。通过非侵入性测量静脉注射的99Tcm硫胶体的血液清除率和肝脏摄取量，来评估肝脏网状内皮系统（RES）的活性。正常大鼠和慢性尿毒症大鼠的血液半衰期及血液清除率常数分别为78±10秒和49.5±5秒，以及7.51±1.04×10⁻³秒⁻¹和10.81±1.17×10⁻³秒⁻¹。正常肝脏摄取率常数为9.03±1.25×10⁻³秒⁻¹，而尿毒症大鼠的摄取率常数为14.34±1.51秒⁻¹。注射后15分钟处死动物时测量肝脏总放射性，结果显示尿毒症时肝脏总摄取量显著增加，而脾脏放射性未观察到变化。本文讨论了这些数据的临床意义。
