Kusewitt D F, Hahn F F, Pickrell J A
Lab Anim Sci. 1982 Jun;32(3):275-7.
Hematologic, serum chemical, and histopathologic studies were performed on 17 aged Fischer 344 rats with mononuclear leukemia. Twelve of the rats had leukemic hemograms, while five had nonleukemic or marginally abnormal differential leukocyte counts. Hematologic findings revealed that all rats were profoundly anemic. Serum chemistry studies confirmed the occurrence of icterus observed clinically, a finding consistent with hemolytic anemia. Alanine aminotransferase and serum alkaline phosphatase values were elevated.
对17只患有单核细胞白血病的老年Fischer 344大鼠进行了血液学、血清化学和组织病理学研究。其中12只大鼠有白血病血常规，而5只大鼠的白细胞分类计数正常或略有异常。血液学检查结果显示，所有大鼠都严重贫血。血清化学研究证实了临床上观察到的黄疸现象，这一发现与溶血性贫血一致。丙氨酸转氨酶和血清碱性磷酸酶值升高。
