Stromberg P C, Vogtsberger L M, Marsh L R, Wilson F D
Vet Pathol. 1983 Nov;20(6):709-17. doi: 10.1177/030098588302000606.
Complete hemograms were evaluated for 57 rats with mononuclear cell leukemia and compared to hemograms obtained from 52 age- and sex-matched nonleukemic rats. All leukemic rats had marked hemolytic anemia and associated spherocytosis, reticulocytosis, anisocytosis, and polychromasia. The anemia varied with the stage of illness and was more severe in rts with advanced leukemia. Death appeared to be related to anemia. There was a marked neutrophilia with left shift, mild lymphopenia, and moderate to severe thrombocytopenia. Atypical mononuclear cells were detected in circulation in all but three rats. Total white blood cell counts ranged from 5.0-370 x 10(3) cells/ml. There was an increase in erythrocyte osmotic fragility with separation into two distinct populations of erythrocytes. Eight of nine rats were Coombs' positive indicating an immune-mediated pathogenesis for the anemia. Hemostasis tests revealed a markedly prolonged prothrombin time, hypofibrinogenemia, slightly increased to normal partial thromboplastin time, and undetected fibrin degradation products. These findings suggest significant liver disease associated with the leukemia.
对57只单核细胞白血病大鼠的全血细胞计数进行评估，并与52只年龄和性别匹配的非白血病大鼠的血细胞计数进行比较。所有白血病大鼠均有明显的溶血性贫血，并伴有球形红细胞增多、网织红细胞增多、红细胞大小不均和嗜多色性。贫血程度随疾病阶段而异，在晚期白血病大鼠中更为严重。死亡似乎与贫血有关。有明显的中性粒细胞增多伴核左移、轻度淋巴细胞减少和中度至重度血小板减少。除3只大鼠外，所有大鼠的循环中均检测到非典型单核细胞。白细胞总数为5.0 - 370×10³个细胞/毫升。红细胞渗透脆性增加，红细胞分为两个不同的群体。9只大鼠中有8只抗人球蛋白试验呈阳性，表明贫血是由免疫介导的发病机制引起的。止血试验显示凝血酶原时间明显延长、纤维蛋白原血症、部分凝血活酶时间略有延长至正常，未检测到纤维蛋白降解产物。这些发现提示与白血病相关的严重肝脏疾病。
