Stromberg P C, Vogtsberger L M, Marsh L R
Vet Pathol. 1983 Nov;20(6):718-26. doi: 10.1177/030098588302000607.
Serum biochemical analyses were done on F344 rats in the early and late stages of mononuclear cell leukemia. There were marked increases in serum bilirubin, alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase and alkaline phosphatase. Increases in these parameters generally were more severe in the late stages of leukemia. Both direct and indirect-reacting bilirubin were increased with the unconjugated form predominating early and the conjugated form predominating late in the course of the disease. Lactate dehydrogenase isoenzyme determination correlated with histological examination indicated that liver damage was responsible for the observed changes. Urinalysis revealed marked hemoglobinuria, bilirubinuria and increased urine urobilinogen. Serum protein electrophoresis revealed marked reductions in the alpha globulin fractions.
对患单核细胞白血病早期和晚期的F344大鼠进行了血清生化分析。血清胆红素、丙氨酸转氨酶、天冬氨酸转氨酶、乳酸脱氢酶和碱性磷酸酶显著升高。这些参数的升高在白血病晚期通常更为严重。在疾病过程中，直接反应胆红素和间接反应胆红素均升高，早期以未结合形式为主，晚期以结合形式为主。乳酸脱氢酶同工酶测定与组织学检查相关，表明肝损伤是观察到的变化的原因。尿液分析显示明显的血红蛋白尿、胆红素尿和尿胆原增加。血清蛋白电泳显示α球蛋白组分显著降低。
