在肝衰竭中显著延长茶碱半衰期。

Markedly prolonged theophylline half-life in liver failure.

作者信息

Baselt R C, Albertson T E

出版信息

J Anal Toxicol. 1982 Mar-Apr;6(2):62-3. doi: 10.1093/jat/6.2.62.

DOI:10.1093/jat/6.2.62

Abstract

Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theophylline clearance and the need for frequent monitoring of plasma theophylline concentrations in cirrhotic patients.

摘要

一名63岁的男性酗酒患者入院后48小时内出现了茶碱中毒，其症状为呼吸急促、水肿和嗜睡。采用液相色谱法，在停药后观察到血清茶碱半衰期为134小时。本报告强调了肝脏疾病对茶碱清除率的影响，以及对肝硬化患者频繁监测血浆茶碱浓度的必要性。