Cushman P, Barboriak J J, Liao A, Hoffman N E
Life Sci. 1982 May 17;30(20):1721-4. doi: 10.1016/0024-3205(82)90305-8.
Seven patients entering an alcoholic detoxification and treatment unit exhibited elevated levels of plasma high density lipoprotein cholesterol (HDLC) and enhanced metabolic disposal of antipyrine. Following a 2-week abstinence treatment, the HDLC levels were reduced by 28% (from 64 to 47 mg/100 ml) and the t 1/2 of antipyrine was extended from 12.4 to 13.7 hours. The extent of the HDLC reduction correlated with the antipyrine t 1/2 changes (r = -0.753, P = 0.05).
七名进入酒精解毒和治疗单元的患者表现出血浆高密度脂蛋白胆固醇（HDLC）水平升高以及安替比林的代谢清除增强。经过为期两周的戒酒治疗后，HDLC水平降低了28%（从64降至47mg/100ml），安替比林的半衰期从12.4小时延长至13.7小时。HDLC降低的程度与安替比林半衰期的变化相关（r = -0.753，P = 0.05）。
