Arch J R, Ainsworth A T, Cawthorne M A
Life Sci. 1982 May 24;30(21):1817-26. doi: 10.1016/0024-3205(82)90319-8.
(-)-Ephedrine has been shown to increase energy expenditure and cause the loss of body fat in rats and mice. The present study compares the effects of (-)- and (+)-ephedrine, (-)- and (+)- pseudoephedrine, (+)- and (+)-norephedrine and (-)- and (+)-norpseudoephedrine on food intake, energy expenditure and body composition in ob/ob and normal mice and food intake in rats. The most potent anorectic and thermogenic compounds had the S configuration at the C-2 position but the orders of potencies for the compounds for anorexia and thermogenesis were not identical. The potencies of the compounds in reducing body lipid content correlated better with their thermogenic than their anorectic potencies.
（-）-麻黄碱已被证明可增加大鼠和小鼠的能量消耗并导致体脂减少。本研究比较了（-）-和（+）-麻黄碱、（-）-和（+）-伪麻黄碱、（+）-和（+）-去甲麻黄碱以及（-）-和（+）-去甲伪麻黄碱对ob/ob小鼠和正常小鼠的食物摄入量、能量消耗及身体组成的影响，以及对大鼠食物摄入量的影响。最有效的食欲抑制剂和产热化合物在C-2位具有S构型，但这些化合物在抑制食欲和产热方面的效力顺序并不相同。这些化合物在降低身体脂质含量方面的效力与其产热效力的相关性比与食欲抑制效力的相关性更好。
