淋巴细胞亚群对易自发细胞毒性或抗自发细胞毒性的细胞系的自发和凝集素依赖性细胞毒性。
Spontaneous and lectin-dependent cellular cytotoxicity by lymphocyte subpopulations against cell lines susceptible or resistant to spontaneous cytotoxicity.
作者信息
Jondal M, Targan S
出版信息
Clin Exp Immunol. 1978 Jul;33(1):121-7.
In the present study we have investigated whether cell lines, which are resistant to spontaneous cytotoxicity, can be killed by lectin-dependent cellular cytotoxicity (LDCC), the expression of EAC (7S) receptors on LDCC effector cells, and the relationship between spontaneous cytotoxicity and LDCC when EAC (7S) receptor-positive or -negative subpopulations are tested against different target cell lines. We found that target cells which are resistant to spontaneous cytotoxicity can, indeed, be killed by LDCC, and that there is an inverse relationship between spontaneous cytotoxicity and LDCC, both when unfractionated lymphocytes were tested against different target cells and when fractionated cells were tested against cell lines highly susceptible to spontaneous cytotoxicity. The implications of these findings, in relation to the relative specificity of the spontaneous cytotoxicity system, are discussed.
在本研究中，我们研究了对自发细胞毒性具有抗性的细胞系是否可被凝集素依赖性细胞毒性（LDCC）杀死，LDCC效应细胞上EAC（7S）受体的表达，以及当针对不同靶细胞系测试EAC（7S）受体阳性或阴性亚群时自发细胞毒性与LDCC之间的关系。我们发现，对自发细胞毒性具有抗性的靶细胞确实可被LDCC杀死，并且当用未分级的淋巴细胞针对不同靶细胞进行测试以及用分级的细胞针对对自发细胞毒性高度敏感的细胞系进行测试时，自发细胞毒性与LDCC之间均呈负相关。讨论了这些发现与自发细胞毒性系统的相对特异性相关的意义。
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