Grenadier E, Alpan G, Keidar S, Palant A
Postgrad Med J. 1982 Mar;58(677):175-7. doi: 10.1136/pgmj.58.677.175.
Four patients are described who exhibited prolonged Q-T intervals, multiple ventricular premature beats and ventricular tachycardia of the ‘torsade de pointes’ configuration whilst on treatment with prenylamine. In two of these patients, advanced atrio-ventricular block was established immediately following intravenous administration of lignocaine. The arrhythmia and the atrio-ventricular blocks were successfully controlled by ventricular pacing. The hazard of the simultaneous administration of these two drugs is stressed.
本文描述了4例患者，这些患者在使用普尼拉明治疗期间出现Q-T间期延长、频发室性早搏以及尖端扭转型室性心动过速。其中2例患者在静脉注射利多卡因后立即出现了高度房室传导阻滞。通过心室起搏成功控制了心律失常和房室传导阻滞。强调了同时使用这两种药物的风险。
