Propper R D
Prog Clin Biol Res. 1982;88:227-33.
Patients requiring chronic transfusions deposit large quantities of iron throughout their reticuloendothelial and parenchymal systems. Diabetes mellitus, hepatic fibrosis, and cardiomyopathy are the ultimate pathologic manifestations. One mechanism for decreasing the rate of iron loading would be to transfuse only the youngest cohort of cells from a donor (neocytes). At the same time the patient's oldest red cells are being removed (neocyte-gerocyte exchange). In this manuscript we describe techniques presently available for such a procedure.
需要长期输血的患者会在其整个网状内皮系统和实质系统中沉积大量铁。糖尿病、肝纤维化和心肌病是最终的病理表现。降低铁负荷率的一种机制是仅输注来自供体的最年轻细胞群（新细胞）。同时，患者最老的红细胞被清除（新细胞 - 衰老细胞交换）。在本手稿中，我们描述了目前可用于此程序的技术。
