Berdoukas V A, Kwan Y L, Sansotta M L
Clin Lab Haematol. 1986;8(3):209-20. doi: 10.1111/j.1365-2257.1986.tb00097.x.
We compared red cell exchange transfusions (RC Ex) on the Aminco Celltrifuge (continuous flow cell separator) with conventional transfusions in 17 patients aged between 7 and 24 years who have transfusion dependent homozygous beta-thalassaemia and two other patients with chronic transfusion dependent anaemias aged 20 and 22. We aimed to return the youngest cohort of cells ('Neocytes') from both donor blood and the patient and to discard older cells ('gerocytes'). Using RC Ex, red cell transfusion requirement was reduced by 30%, reducing significantly the iron load, and the transfusion interval was increased by 43%. There is a great demand by the patients to continue this therapy as they have appreciated the immediate benefit of reduced hospitalization.
我们将17名年龄在7至24岁之间依赖输血的纯合子β地中海贫血患者以及另外两名分别为20岁和22岁的依赖慢性输血的贫血患者，在Aminco Celltrifuge（连续流式细胞分离器）上进行的红细胞置换输血（RC Ex）与传统输血进行了比较。我们的目标是从供体血液和患者体内回输最年轻的细胞群（“新生细胞”），并丢弃较老的细胞（“衰老细胞”）。使用RC Ex后，红细胞输血需求量减少了30%，显著降低了铁负荷，输血间隔延长了43%。患者对继续这种治疗有很大需求，因为他们已经认识到减少住院时间带来的直接益处。
