Tandon S K, Khandelwal S
Res Commun Chem Pathol Pharmacol. 1982 May;36(2):337-40.
The influence of some selected polyaminocarboxylic acids and thiol metal binding agents on the urinary and faecal excretions of 54Mn and on the tissue distribution of 54Mn in 54MnCl2 administered rats was studied to find a suitable chelating drug for Mn poisoning. HEDTA, CDTA, DTPA and TTHA were highly successful in enhancing the excretion of 54Mn and reducing the tissue levels of 54Mn in rats. The thiol chelators viz. D L-penicillamine, N-acetyl D L-penicillamine and DMS could neither influence the excretion nor the tissue distribution of 54Mn suggesting poor affinity of the metal towards sulfhydryl groups.
为找到一种适用于锰中毒的螯合药物，研究了某些选定的聚氨基羧酸和硫醇金属结合剂对54MnCl2给药大鼠尿和粪便中54Mn排泄以及54Mn组织分布的影响。HEDTA、CDTA、DTPA和TTHA在增强大鼠54Mn排泄及降低54Mn组织水平方面非常成功。硫醇螯合剂，即DL-青霉胺、N-乙酰-DL-青霉胺和二巯基丁二酸，既不影响54Mn的排泄，也不影响其组织分布，这表明该金属对巯基的亲和力较差。
