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Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.

作者信息

Ito N, Tsuda H, Sakata T, Hasegawa R, Tamano S

出版信息

Gan. 1983 Aug;74(4):466-8.

PMID:6628899
Abstract

The effect of butylated hydroxyanisole (BHA) and ethoxyquin (EQ) on hepatocarcinogenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats was investigated. The results clearly demonstrated that BHA and EQ inhibited the development of gamma-glutamyltranspeptidase - positive foci, hyperplastic nodules and hepatocellular carcinomas in the rat system employed.

摘要

相似文献

1
Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.
Gan. 1983 Aug;74(4):466-8.
2
Modifying effects of butylated hydroxyanisole, ethoxyquin and acetaminophen on induction of neoplastic lesions in rat liver and kidney initiated by N-ethyl-N-hydroxyethylnitrosamine.丁基羟基茴香醚、乙氧喹和对乙酰氨基酚对N-乙基-N-羟乙基亚硝胺引发的大鼠肝脏和肾脏肿瘤性病变诱导的修饰作用。
Carcinogenesis. 1984 Apr;5(4):525-31. doi: 10.1093/carcin/5.4.525.
3
Inhibitory effect of antioxidants ethoxyquin and 2(3)-tert-butyl-4-hydroxyanisole on hepatic tumorigenesis in rats fed ciprofibrate, a peroxisome proliferator.抗氧化剂乙氧喹和2(3)-叔丁基-4-羟基茴香醚对喂食过氧化物酶体增殖剂环丙贝特的大鼠肝脏肿瘤发生的抑制作用。
Cancer Res. 1984 Mar;44(3):1072-6.
4
Modification of carcinogenesis by antioxidants and other compounds.抗氧化剂及其他化合物对致癌作用的影响
Acta Pharmacol Toxicol (Copenh). 1984;55 Suppl 2:125-43. doi: 10.1111/j.1600-0773.1984.tb02486.x.
5
Dose-dependent effects of butylated hydroxyanisole, butylated hydroxytoluene and ethoxyquin in induction of foci of rat liver cells containing the placental form of glutathione S-transferase.丁基羟基茴香醚、丁基羟基甲苯和乙氧喹啉对诱导含有胎盘型谷胱甘肽S-转移酶的大鼠肝细胞灶的剂量依赖性效应。
Cancer Lett. 1985 Jul;27(3):295-303. doi: 10.1016/0304-3835(85)90187-9.
6
Protective effects of butylated hydroxyanisole, ethoxyquin, and disulfiram on acute pyrrolizidine alkaloids poisoning in mice.丁基羟基茴香醚、乙氧喹和双硫仑对小鼠急性吡咯里西啶生物碱中毒的保护作用。
Res Commun Chem Pathol Pharmacol. 1982 May;36(2):341-4.
7
Inhibitory effects of ethoxyquin, 4,4'-diaminodiphenylmethane and acetaminophen on rat hepatocarcinogenesis.
Jpn J Cancer Res. 1986 Mar;77(3):231-7.
8
Promoting activities of butylated hydroxyanisole and butylated hydroxytoluene on 2-stage urinary bladder carcinogenesis and inhibition of gamma-glutamyl transpeptidase-positive foci development in the liver of rats.丁基羟基茴香醚和丁基羟基甲苯对大鼠两阶段膀胱致癌作用的促进活动以及对大鼠肝脏中γ-谷氨酰转肽酶阳性灶发展的抑制作用。
Carcinogenesis. 1983;4(7):895-9. doi: 10.1093/carcin/4.7.895.
9
Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.在喂食酚类抗氧化剂、乙氧喹和二硫代硫酮的大鼠体内，黄曲霉毒素B1与DNA结合的修饰作用。
Carcinogenesis. 1985 May;6(5):759-63. doi: 10.1093/carcin/6.5.759.
10
Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.乙氧喹啉喂养大鼠中黄曲霉毒素代谢、黄曲霉毒素-N7-鸟嘌呤形成及肝脏肿瘤发生的调节：谷胱甘肽S-转移酶诱导的作用。
Cancer Res. 1986 Aug;46(8):3924-31.

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Jpn J Cancer Res. 1991 Nov;82(11):1211-9. doi: 10.1111/j.1349-7006.1991.tb01783.x.