Gioud M, Ait Kaci A, Sepetjan M, Monier J C
Rev Rhum Mal Osteoartic. 1982 Apr;49(5):385-91.
Use of an immunoenzyme technique to seek two types of antibody (AB): antihistones and bicatenary anti-RNA, led to study of their distribution in different connective tissue and autoimmune diseases. Total antihistone AB and the H1 and H2b antifractions were seen almost exclusively in lupus (52.5 per cent of cases), principally during active phases of the disease since 87 per cent of active forms had antihistone AB as against 15 per cent of inactive forms. Antihistone AB would thus appear to be a valuable laboratory investigation in the diagnosis and surveillance of lupus. Bicatenary anti-RNA AB were more widely distributed, being found in DLE, RA, scleroderma and in various disorders with antinuclear antibodies. However they were slightly more common in active forms of lupus and their titres appeared to fall more quickly than those of antinuclear AB and anti-DNA AB at the time of clinical improvements. In RA, bicatenary anti-RNA AB were more commonly associated with inflammatory and progressive forms but further studies involving larger populations would be necessary to confirm these findings.
运用免疫酶技术寻找两种抗体（AB）：抗组蛋白抗体和双链抗RNA抗体，从而对它们在不同结缔组织病和自身免疫性疾病中的分布进行研究。总抗组蛋白AB以及H1和H2b抗组分几乎仅在狼疮患者中出现（占病例的52.5%），主要在疾病的活动期，因为87%的活动型狼疮患者有抗组蛋白AB，而不活动型患者中这一比例为15%。因此，抗组蛋白AB似乎是狼疮诊断和监测中有价值的实验室检查项目。双链抗RNA AB分布更为广泛，见于盘状红斑狼疮（DLE）、类风湿关节炎（RA）、硬皮病以及各种有抗核抗体的疾病中。然而，它们在活动型狼疮中略为常见，而且在临床病情改善时，其滴度似乎比抗核AB和抗DNA AB下降得更快。在类风湿关节炎中，双链抗RNA AB更常与炎症性和进行性类型相关，但需要开展涉及更多人群的进一步研究来证实这些发现。
