鱼精蛋白对氨基核苷肾病蛋白尿和肾小球硬化的影响。
The effect of protamine on proteinuria and glomerular sclerosis in aminonucleoside nephropathy.
作者信息
Saito T, Yamakage K, Kurosawa K, Kyogoku Y, Furuyama T, Yoshinaga K
出版信息
Tohoku J Exp Med. 1982 Apr;136(4):461-2. doi: 10.1620/tjem.136.461.
PMID:7101279
Abstract
An administration of protamine sulfate combined with aminonucleoside of puromycin (AN) could produce in rats severe nephrotic syndrome and histological changes similar to focal glomerular sclerosis more distinctly than AN alone. This may be attributed to the action of protamine which seemed to enhance the effect of AN, causing polyanion loss at the glomerular basement membrane.
摘要
硫酸鱼精蛋白与嘌呤霉素氨基核苷（AN）联合给药，相比于单独使用AN，能在大鼠身上更明显地引发严重肾病综合征以及类似于局灶性肾小球硬化的组织学变化。这可能归因于鱼精蛋白的作用，它似乎增强了AN的效果，导致肾小球基底膜上的聚阴离子丢失。
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