Yamamoto K, Yamamoto Y, Hattori H, Samori T
Tohoku J Exp Med. 1982 May;137(1):73-8. doi: 10.1620/tjem.137.73.
Cyanide concentrations in various organs (the blood, liver, lung, spleen and brain) of the rats intoxicated by ingestion or inhalation were determined with a slightly modified microdiffusion method. In the inhalation experiment, a rat in an exposure chamber inhaled HCN produced by addition of NaCN solution to H2SO4. For each route two different doses were used. The time to death was shorter when doses were larger. Cyanide concentrations were higher in per os group than in inhalation group in all the organs tested. The concentration in the liver was most sensitive to the route of administration; it was the highest among the organs tested after per os administration, but low after inhalation. In the lung it was significantly higher than that of the blood when cyanide was inhaled. It was concluded that, when it is necessary to determine whether cyanide was ingested to inhaled, at least the lung and liver must be analyzed for cyanide contents in addition to the blood and stomach content.
采用略有改进的微量扩散法测定经口摄入或吸入中毒大鼠各器官（血液、肝脏、肺、脾脏和大脑）中的氰化物浓度。在吸入实验中，暴露箱中的大鼠吸入通过向硫酸中添加氰化钠溶液产生的氰化氢。每种途径使用两种不同剂量。剂量越大，死亡时间越短。在所有测试器官中，经口给药组的氰化物浓度高于吸入组。肝脏中的浓度对给药途径最为敏感；经口给药后，它在测试器官中最高，但吸入后较低。吸入氰化物时，肺中的浓度显著高于血液中的浓度。得出的结论是，当有必要确定氰化物是经口摄入还是吸入时，除了血液和胃内容物外，至少还必须分析肺和肝脏中的氰化物含量。
