Yamamoto K, Yamamoto Y, Kuwahara C
Z Rechtsmed. 1979 Oct;83(4):313-7. doi: 10.1007/BF01882177.
Blood cyanide concentration was determined in rabbits intoxicated orally or by inhalation. Experiments were carried out under urethane anaesthesia. In the inhalation experiments, rabbits inhaled a combustion product containing HCN via the tracheal cannula and in the oral studies animals were administered NaCN solution into the stomach. In addition to the carotid artery and jugular vein blood samples, postmortem samples were obtained from both sides of the heart and the descending vena cava. The arterial cyanide concentration in the inhalation group showed a close relationship with ventilation. After an initial rise, blood levels decreased a little, in some cases with transient apnea. At the last stage it again increased with gasping, reaching its maximal value. After ultimate apnea, the blood cyanide concentration declined. The blood cyanide values were higher in the oral group than in the inhalation group. The difference between the two groups became larger in the inferior order, the left heart blood--the right heart blood--blood in the descending vena cava. The left heart/right heart ratio of the inhalation group was significantly higher than that of the oral group (1.28+/- 0.28 vs. 0.95+/- 0.09). The coefficient of variation (c.v.) of the inhalation group was larger than that of the other group. Within the inhalation group, the left heart blood showed the largest c.v. values and this was probably due to redistribution of the cyanide by bloodstream after attainment of the maximal concentration.
测定经口或经吸入中毒的家兔的血液氰化物浓度。实验在氨基甲酸乙酯麻醉下进行。在吸入实验中，家兔通过气管插管吸入含氰化氢的燃烧产物，在经口研究中，将氰化钠溶液灌入动物胃内。除采集颈动脉和颈静脉血样外，还从心脏两侧和下腔静脉采集死后样本。吸入组的动脉氰化物浓度与通气密切相关。起初有所上升，之后血药浓度略有下降，有些情况下伴有短暂呼吸暂停。在最后阶段，随着喘息再次升高，达到最大值。在最终呼吸暂停后，血液氰化物浓度下降。经口组的血液氰化物值高于吸入组。两组之间的差异在下腔静脉血、右心血液、左心血液的顺序中变得更大。吸入组的左心/右心比率显著高于经口组（1.28±0.28对0.95±0.09）。吸入组的变异系数（c.v.）大于另一组。在吸入组内，左心血液的c.v.值最大，这可能是由于达到最大浓度后氰化物通过血流重新分布所致。
