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一种用日本血吸虫感染实验小鼠的快速方法。

A rapid method for the infection of laboratory mice with Schistosoma japonicum.

作者信息

Moloney N A, Webbe G

出版信息

Trans R Soc Trop Med Hyg. 1982;76(2):200-3. doi: 10.1016/0035-9203(82)90274-7.

DOI:10.1016/0035-9203(82)90274-7
PMID:7101404
Abstract

Known numbers of medium-suspended cercariae of Schistosoma japonicum were injected either intraperitoneally, subcutaneously, intramuscularly or intravenously into mice and were compared for infectivity with S. japonicum cercariae that had been administered percutaneously. The injected cercariae appeared to be no less infective or fecund even after their maintenance in vitro for up to six hours. The intraperitoneal route of inoculation was preferred as it facilitated the rapid infection of mice and furthermore was much safer than conventional percutaneous application of cercariae.

摘要

将已知数量的日本血吸虫中期悬浮尾蚴经腹腔、皮下、肌肉或静脉注射到小鼠体内,并与经皮给予的日本血吸虫尾蚴的感染性进行比较。即使在体外保存长达6小时后,注射的尾蚴似乎仍具有同样的感染性和繁殖力。腹腔接种途径更受青睐,因为它有助于小鼠快速感染,而且比传统的经皮施用尾蚴要安全得多。

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