Platelet adenine nucleotide levels during room-temperature storage of platelet concentrates.

Platelet adenine nucleotide levels were measured in freshly prepared platelet concentrates and daily during storage at room temperature. Marked depletions in platelet adenosine triphosphate (ATP) and adenosine diphosphate (ADP) levels were associated with decrease in both plasma glucose levels and poststorage pH. In those concentrates with only moderate glucose consumption, platelet ATP and ADP levels were well preserved and the plasma pH remained above 6.0. The rate of glucose utilization and poststorage pH were greatly influenced by the concentration of contaminating leukocytes. These studies indicate that the rate of exogenous glucose consumption is an important factor affecting platelet adenine nucleotide levels during room temperature storage of platelet concentrates.