[Functional importance of catecholamine metabolism in the regulation of AMP-aminohydrolase activity in mitochondria of the heart and other organs].

The paper deals with main pathways for conversion of catecholamines and their effect on the activity of AMP-aminohydrolase in mitochondria of the heart, liver, brain, kidneys and blood serum. Dopamine-beta hydroxylase is stated to participate in manifestation of dopamine effect on the heart AMP-aminohydrolase, the same may be said with respect to monoaminooxidase in realization of the norepinephrine action on the brain AMP-aminohydrolase. Adrenoxyl (stabilized adrenochrome) duplicates the catecholamine effect with respect to AMP-aminohydrolase in certain organs. A three-hour electric stimulation of the aorta arc is accompanied by activation of AMP-aminohydrolase in the heart and blood serum, which is, probably, associated with changes in the balance and metabolism of tissue catecholamines. Data of the AMP-aminohydrolase activity determination may be applied for testing the myocardium damage. AMP-aminohydrolase is discussed for its role in realization of the adrenochrome effect on the myocardium adenylate cyclase.