Tapbergenov S O
Ukr Biokhim Zh (1978). 1982 May-Jun;54(3):254-8.
The paper deals with main pathways for conversion of catecholamines and their effect on the activity of AMP-aminohydrolase in mitochondria of the heart, liver, brain, kidneys and blood serum. Dopamine-beta hydroxylase is stated to participate in manifestation of dopamine effect on the heart AMP-aminohydrolase, the same may be said with respect to monoaminooxidase in realization of the norepinephrine action on the brain AMP-aminohydrolase. Adrenoxyl (stabilized adrenochrome) duplicates the catecholamine effect with respect to AMP-aminohydrolase in certain organs. A three-hour electric stimulation of the aorta arc is accompanied by activation of AMP-aminohydrolase in the heart and blood serum, which is, probably, associated with changes in the balance and metabolism of tissue catecholamines. Data of the AMP-aminohydrolase activity determination may be applied for testing the myocardium damage. AMP-aminohydrolase is discussed for its role in realization of the adrenochrome effect on the myocardium adenylate cyclase.
本文探讨了儿茶酚胺的主要转化途径及其对心脏、肝脏、大脑、肾脏线粒体和血清中AMP-氨基水解酶活性的影响。据指出，多巴胺-β-羟化酶参与多巴胺对心脏AMP-氨基水解酶作用的表现，就去甲肾上腺素对大脑AMP-氨基水解酶的作用而言，单胺氧化酶也可能如此。肾上腺色素（稳定化肾上腺素）在某些器官中对AMP-氨基水解酶具有与儿茶酚胺类似的作用。对主动脉弓进行三小时电刺激会伴随着心脏和血清中AMP-氨基水解酶的激活，这可能与组织儿茶酚胺的平衡和代谢变化有关。AMP-氨基水解酶活性测定数据可用于检测心肌损伤。文中还讨论了AMP-氨基水解酶在实现肾上腺色素对心肌腺苷酸环化酶作用中的作用。
