Thibos L N, Levick W R
Vision Res. 1982;22(1):43-53. doi: 10.1016/0042-6989(82)90165-1.
Kittens were deprived of clear vision in one eye only by +7D or -7D cylindrical lenses worn from eye opening until 7.5 months of age. Behavioral measurements subsequently demonstrated diminished acuity through the affected eye relative to the opposite control eye. However, single unit recordings at 3.5 years of age from retinal ganglion cells located within 1-11 degrees of the centre of the area centralis showed neither loss of grating resolution nor any abnormal orientation bias. Furthermore, the astigmatic rearing had minimal effect on the development of the cat's natural optics to the emmetropic state. The experiments indicate that the amblyopic defect induced by the cylindrical lenses occurs in the brain rather than the eye.
从睁眼到7.5月龄期间，小猫仅通过佩戴+7D或-7D柱面透镜使一只眼睛失去清晰视力。随后的行为测量表明，与对侧对照眼相比，受影响眼睛的视力有所下降。然而，在3.5岁时，对位于中央凹中心1-11度范围内的视网膜神经节细胞进行的单细胞记录显示，光栅分辨率既没有损失，也没有任何异常的方向偏差。此外，散光饲养对猫的自然光学系统向正视状态的发育影响极小。这些实验表明，柱面透镜引起的弱视缺陷发生在大脑而非眼睛。
