Stanchev I N
Vutr Boles. 1982;21(2):55-60.
The results are presented from a meticulous genealogical study, to III stage of family descent, of 348 patients with duodenal ulcer and 101 healthy subjects. The index of hereditary defects, with the strictly collected data, revealed that in 3/4 of the patients degree greater than families some other representatives with ulcer disease were found. With broadening the circle and including more relatives, that index regularly grows. The incidence of ulcer diseases among the relatives of the propositus with duodenal ulcer is 5 to 10 times more frequent as compared with the corresponding stages of kinship among the healthy controls. The duodenal ulcer, in the hereditary defective patients, is manifested with an average of 8--10 years earlier. The same localization of the ulcer niche was found in 91.12 per cent among the blood relatives of the propositi. The males suffer 2.5 times more often from duodenal ulcer.
研究结果来自一项细致的系谱学研究，该研究对348例十二指肠溃疡患者和101名健康受试者进行了至家族三代的追踪。通过严格收集的数据得出的遗传缺陷指数显示，在四分之三的患者家族中，发现患有溃疡病的其他亲属比例更高。随着研究范围扩大并纳入更多亲属，该指数会有规律地上升。与健康对照相应亲属阶段相比，十二指肠溃疡先证者亲属中溃疡病的发病率要高5至10倍。在遗传缺陷患者中，十二指肠溃疡的发病平均要早8至10年。在先证者的血亲中，91.12%的人溃疡龛的位置相同。男性患十二指肠溃疡的几率是女性的2.5倍。
