Loewit K, Kraft H G, Brabec W
Wien Klin Wochenschr. 1982 Apr 16;94(8):223-6.
A modified Zimmermann reaction (detection of 17-keto-steroids) has been tested for its applicability to fetal sex diagnosis after 20 weeks of pregnancy. In 90 pregnant women the overall reliability of prediction was only 52%. It increased, however, to 67% by analyzing non-morning samples of saliva, while it decreased to 40% if the first saliva was collected. The sensitivity of the method was found to be unequivocally too low to measure salivary androgens. While this procedure in its present form is not suited to antenatal sex determination, further studies of the still unknown nature of the colour reaction might lead to a new understanding of the changes in salivary composition during pregnancy.
一种改良的齐默尔曼反应（检测17-酮类固醇）已被测试其在妊娠20周后用于胎儿性别诊断的适用性。在90名孕妇中，预测的总体可靠性仅为52%。然而，通过分析非早晨的唾液样本，可靠性提高到了67%，而如果收集的是第一口唾液，可靠性则降至40%。发现该方法的灵敏度明显过低，无法测量唾液雄激素。虽然目前这种方法不适合产前性别鉴定，但对仍不明了的显色反应性质的进一步研究可能会使人们对孕期唾液成分的变化有新的认识。
