Pakkanen A, Kanto J
Acta Anaesthesiol Scand. 1982 Apr;26(2):143-6. doi: 10.1111/j.1399-6576.1982.tb01742.x.
In patients premedicated with scopolamine + morphine (+5 mg nitrazepam the evening before surgery), the sleep-inducing effect of midazolam 0.15 mg/kg i.v. was clearly slower in onset than that of thiopentone 4.67 mg/kg i.v. Somewhat fewer cardiovascular and local sequelae were found in the midazolam group, but, although apnoea occurred less often in the midazolam group it lasted longer. On the whole, the differences between midazolam and thiopentone had no apparent clinical consequences. Midazolam is a new alternative agent for induction in combination anaesthesia.
在术前用东莨菪碱+吗啡（手术前一晚加用5毫克硝西泮）进行预处理的患者中，静脉注射0.15毫克/千克咪达唑仑的催眠起效明显慢于静脉注射4.67毫克/千克硫喷妥钠。咪达唑仑组出现的心血管和局部后遗症略少，但尽管咪达唑仑组呼吸暂停发生频率较低，但其持续时间较长。总体而言，咪达唑仑和硫喷妥钠之间的差异没有明显的临床后果。咪达唑仑是联合麻醉诱导的一种新的替代药物。
