Kanto J, Sjövall S, Vuori A
Br J Anaesth. 1982 May;54(5):507-11. doi: 10.1093/bja/54.5.507.
The effects of different premedication (i.m. and i.v.) on the usefulness of midazolam or thiopentone as induction agents for minor surgery was studied in 194 women undergoing either dilatation and curettage or explorative fractionate curettage. Midazolam appeared to produce light sedation which required powerful premedication (i.m. atropine + pethidine and i.v. fentanyl or fentanyl + dehydrobenzperidol) when used as an induction agent for minor surgery. The clinically useful dose of midazolam is about 0.30 mg kg-1 i.v. There was greater variability in onset and duration of action among patients receiving midazolam than among those receiving thiopentone. Midazolam caused less respiratory depression, but there were no clinically significant differences between midazolam and thiopentone with respect to cardiovascular variables. Muscular movements were found more often, and postoperative sedation lasted longer in patients receiving midazolam. Midazolam as an induction agent appears more suited for major than for minor surgery.
在194名接受刮宫术或分段诊断性刮宫术的女性患者中，研究了不同预处理方式（肌内注射和静脉注射）对咪达唑仑或硫喷妥钠作为小手术诱导剂有效性的影响。当咪达唑仑用作小手术诱导剂时，似乎会产生轻度镇静作用，这需要强效预处理（肌内注射阿托品+哌替啶以及静脉注射芬太尼或芬太尼+脱氢苯哌利多）。咪达唑仑的临床有效剂量约为静脉注射0.30mg/kg。接受咪达唑仑的患者之间起效时间和作用持续时间的变异性比接受硫喷妥钠的患者更大。咪达唑仑引起的呼吸抑制较轻，但在心血管变量方面，咪达唑仑和硫喷妥钠之间没有临床显著差异。接受咪达唑仑的患者更常出现肌肉运动，且术后镇静持续时间更长。咪达唑仑作为诱导剂似乎更适合大手术而非小手术。
